Trypanosoma Cruzi: major clones rather than principal zymodemes

Chagas' cardiopathy and Trypanosoma cruzi zymodemes in Chile.

Chagas’ disease, the most widespread parasitic ailment in Latin America, produces clinical pictures with regional variations (1). In Chile, due to the country’s geographic and ecologic isolation, specific local conditions influencing Chagas’ disease vectors differ from those prevailing in other countries. One such vector, Triatoma spinohi, has not been found in other geographic areas. Among oth...

Trypanosoma cruzi: clonal structure of parasite strains and the importance of principal clones.

Different behavior of two Trypanosoma cruzi major clones: transmission and circulation in young Bolivian patients.

Specificity of two widespread Trypanosoma cruzi clonal genotypes or "clonets" (20 and 39) was first analyzed by hybridization with a large set of T. cruzi stocks characterized by multigenic study relying on both MLEE and RAPD. Then, these clonets were detected in the blood of Chagasic children from a Bolivian endemic area by a combination of polymerase chain reaction and clonet-specific DNA hyb...

Trypanosoma cruzi populations: more clonal than sexual.

The ancient question of trypanosome sexuality has recently been reactivated in view of important observations in the African species Trypanosoma brucie, in which Mendelian sexuality has been proposed as a working hypothesis on the basis o f indirect isozyme evidence. Subsequent experiments have confirmed that recombination can occur in T. brucei under defined experimental conditions and suggest...

Association between Trypanosoma cruzi zymodemes and specific humoral depression in chronic chagasic patients.

I' References Apted, F. I. C. (1980). Present status of chemotherapy and chemoprophylaxis of human trypanosomiasis in the eastern hemisphere. Pharmacology and Therapeutics, 11, 391-413. DoKa, F , Boa, F. Y., Schechter, P. J., Miezan, T. W., Dia, D., Sanon, S. R., de Raadt, P., Haegele, K. D., Sjoerdsma, A. & Konian, K. (1987). Treatment of human late-stage gambiense trypanosomiasis with ordiflu...